Contaje y volumen plaquetario medio asociados al dengue en pacientes atendidos en el Hospital del Dia Jipijapa, 2023
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Pathak B, Chakravarty A, Krishnan A. High viral load positively correlates with thrombocytopenia and elevated haematocrit in dengue infected paediatric patients. J Infect Public Health. 2021; 14(11):1701-1707. doi: 10.1016/j.jiph.2021.10.002. PMID: 34655984.
Jacob AA, Joseph E, Poothiode U. Significance of platelet indices in dengue fever patients. Int J Med Sci Clin Res Rev. 2022; 5 (5):531–539. https://ijmscrr.in/index.php/ijmscrr/article/view/271
Organización Panamericana de la Salud. OPS. Actualización Epidemiológica: Aumento de casos de dengue en la Región de las Américas. 2024. Disponible en: https://www.paho.org/es/documentos/actualizacion-epidemiologica-aumento-casos-dengue-region-americas-18-junio-2024
Ministerio de Salud Pública. Ecuador. Subsecretaria de Vigilancia, Prevención y Control de la Salud. Dirección Nacional de Vigilancia Epidemiológica. Enfermedades Transmitidas por Vectores. Dengue, Semanas epidemiológicas 1 a 22, año 2024. Disponible en: https://www.salud.gob.ec/wp-content/uploads/2024/06/Eventos-VECTORIALES-SE-22-.pdf
Sangkaew S, Ming D, Boonyasiri A, Honeyford K, Kalayanarooj S, Yacoub S, et al. Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis. Lancet Infect Dis. 2021; 21(7):1014-1026. doi: 10.1016/S1473-3099(20)30601-0. PMID: 33640077; PMCID: PMC8240557.
Madineni KU, Prasad SVN, Bhuma V. A study of the prognostic significance of platelet distribution width, mean platelet volume, and plateletcrit in cerebral venous sinus thrombosis. J Neurosci Rural Pract. 2023;14(3):418-423. doi: 10.25259/JNRP-2021-1-3-R2-(1431). PMID: 37692829; PMCID: PMC10483190.
Organización Mundial de la Salud. OMS. Dengue y dengue grave. 2022. Disponible en: https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue.
Balière C, Calvez E, Thiberge JM, Somlor S, Vandenbogaert M, Grandadam M, et al. A Six Years (2010-2016) Longitudinal Survey of the Four Serotypes of Dengue Viruses in Lao PDR. Microorganisms. 2023;11(2):243. doi: 10.3390/microorganisms11020243. PMID: 36838207; PMCID: PMC9959689.
Wilastonegoro NN, Andriani S, Sebong PH, Agarwal-Harding P, Shepard DS. Estimating dengue disease and economic burden to inform municipal-level policymakers: Method for a pragmatic city-level observational cohort study. Gates Open Res. 2024; 8:3. doi: 10.12688/gatesopenres.15015.3. PMID: 39221028; PMCID: PMC11362393.
Soomar SM, Issani A, Moin G, Dhalla Z, Adnan A, Soomar SM. The Serological Confirmation and Outcome of the Pediatric Dengue Patients Presenting to Emergency Department: A Cross-Sectional Study. Glob Pediatr Health. 2022; 9:2333794X221138434. doi: 10.1177/2333794X221138434.
Cherie TJJ, Choong CSH, Abid MB, Weber MW, Yap ES, Seneviratne SL, et al. Immuno-Haematologic Aspects of Dengue Infection: Biologic Insights and Clinical Implications. Viruses. 2024;16(7):1090. doi: 10.3390/v16071090. PMID: 39066252; PMCID: PMC11281699.
Lue AM, Richards-Dawson MEH, Gordon-Strachan GM, Kodilinye SM, Dunkley-Thompson JAT, James-Powell TD, et al. Severity and Outcomes of Dengue in Hospitalized Jamaican Children in 2018-2019 During an Epidemic Surge in the Americas. Front Med (Lausanne). 2022; 9:889998. doi: 10.3389/fmed.2022.889998. PMID: 35801209; PMCID: PMC9254731.
Quirino-Teixeira AC, Andrade FB, Pinheiro MBM, Rozini SV, Hottz ED. Platelets in dengue infection: more than a numbers game. Platelets. 2022;33(2):176-183. doi: 10.1080/09537104.2021.1921722. PMID: 34027810.
Sontakke RA, Aglave NR, Dua H. Correlation of platelet parameters with the severity of thrombocytopenia in dengue fever in children aged less than 18 years at a tertiary care centre: A Cross-Sectional Study. Cureus. 2024;16(3): e56829. doi: 10.7759/cureus.56829. PMID: 38654784; PMCID: PMC11037499.
Vuong NL, Quyen NTH, Tien NTH, Duong Thi Hue K, Duyen HTL, Lam PK, et al. Dengue viremia kinetics and effects on platelet count and clinical outcomes: An analysis of 2340 patients from Vietnam. Elife. 2024; 13:RP92606. doi: 10.7554/eLife.92606. PMID: 38904662; PMCID: PMC11192532.
Balakrishna Pillai AK, Chu JJH, Mariappan V, JeanPierre AR. Platelets in the pathogenesis of flavivirus disease. Curr Opin Virol. 2022; 52:220-228. doi: 10.1016/j.coviro.2021.12.007. PMID: 34968791.
Acosta-España JD, Dueñas-Espín I, Grijalva Narvaez DF, Altamirano-Jara JB, Gómez-Jaramillo AM, Rodriguez-Morales AJ. Analysis of inpatient data on dengue fever, malaria and leishmaniasis in Ecuador: A cross-sectional national study, 2015-2022. New Microbes New Infect. 2024; 60-61:101421. doi: 10.1016/j.nmni.2024.101421. PMID: 38818245; PMCID: PMC11137557.
Ministerio de Salud Pública. Subsecretaria de Vigilancia de la Salud Pública. Dirección Nacional de Vigilancia Epidemiológica. Gaceta Epidemiológica año 2023. SIVEALERTA SE 50. Disponible en: https://www.salud.gob.ec/wp-content/uploads/2023/12/Gaceta-de-Vectoriales-SE-50.pdf
Organización Panamericana de la Salud. Síntesis de evidencia: Directrices para el diagnóstico y el tratamiento del dengue, chikunguña y zika en la Región de las Américas. Rev Panam Salud Publica. 2022; 46: e82. Spanish. doi: 10.26633/RPSP.2022.82. PMID: 35875317; PMCID: PMC9299388.
Ramos-Castañeda J, Barreto dos Santos F, Martínez-Vega R, Galvão de Araujo JM, Joint G, Sarti E. Dengue in Latin America: Systematic Review of Molecular Epidemiological Trends. PLoS Negl Trop Dis. 2017;11(1): e0005224. Disponible en: https://doi.org/10.1371/journal.pntd.0005224. doi: 10.1371/journal.pntd.0005224 PMID 28068335 PMCID PMC5221820.
Instituto Nacional de Investigación en Salud Pública (INSPI). Sistema Nacional de Vigilancia y Alerta Temprana para el Control del Vector de Dengue y Fiebre Amarilla (Fase 1). Disponible en: https://www.investigacionsalud.gob.ec/webs/cirev/proyectos-2/satvec-dengue/
Organización de las Naciones Unidas. Objetivos de Desarrollo Sostenible. ODS agenda 2030. 2015. Disponible en: https://www.un.org/sustainabledevelopment/es/objetivos-de-desarrollo-sostenible/
Secretaria Nacional de Planificación. República del Ecuador. 2024. Plan de Desarrollo para el Nuevo Ecuador 2024-2025. Disponible en: https://www.planificacion.gob.ec/plan-de-desarrollo-para-el-nuevo-ecuador-2024-2025/
Nandwani S, Bhakhri BK, Singh N, Rai R, Singh DK. Early hematological parameters as predictors for outcomes in children with dengue in northern India: A retrospective analysis. Rev Soc Bras Med Trop. 2021; 54: e05192020. doi: 10.1590/0037-8682-0519-2020. PMID: 33533817; PMCID: PMC7849329.
Islam S, Khan MAS, Badal MFA, Khan MZI, Gozal D, Hasan MJ. Clinical and hematological profiles of children with dengue residing in a non-endemic zone of Bangladesh. PLoS Negl Trop Dis. 2022; 16(10): e0010847. doi: 10.1371/journal.pntd.0010847. PMID: 36215330; PMCID: PMC9584401.
Rosenberger KD, Phung Khanh L, Tobian F, Chanpheaktra N, Kumar V, Lum LCS, et al; International Research Consortium on Dengue Risk Assessment, Management, and Surveillance Investigators. Early diagnostic indicators of dengue versus other febrile illnesses in Asia and Latin America (IDAMS study): a multicentre, prospective, observational study. Lancet Glob Health. 2023; 11(3): e361-e372. doi: 10.1016/S2214-109X(22)00514-9. PMID: 36796983.
Idrus NL, Md Jamal S, Abu Bakar A, Embong H, Ahmad NS. Comparison of clinical and laboratory characteristics between severe and non-severe dengue in paediatrics. PLoS Negl Trop Dis. 2023;17(12): e0011839. doi: 10.1371/journal.pntd.0011839. PMID: 38113250; PMCID: PMC10763952.
Moallemi S, Lloyd AR, Rodrigo C. Early biomarkers for prediction of severe manifestations of dengue fever: a systematic review and a meta-analysis. Sci Rep. 2023;13(1):17485. doi: 10.1038/s41598-023-44559-9. PMID: 37838744; PMCID: PMC10576797.
Tejo AM, Hamasaki DT, Menezes LM, Ho YL. Severe dengue in the intensive care unit. J Intensive Med. 2023; 4(1):16-33. doi: 10.1016/j.jointm.2023.07.007. PMID: 38263966; PMCID: PMC10800775.
Sunari IGAAEP, Aryati A, Hakim FKN, Tanzilia MF, Zuroidah N, Wrahatnala BJ, et al. Non-structural protein 1 and hematology parameters as predictors of dengue virus infection severity in Indonesia. J Med Life. 2023;16(10):1546-1551. doi: 10.25122/jml-2022-0300. PMID: 38313186; PMCID: PMC10835564.
Chanh HQ, Trieu HT, Tran Kim H, Huynh Ngoc Thien V, Huyen VNT, Moncada A, et al. Kinetics of cardiovascular and inflammatory biomarkers in paediatric dengue shock syndrome. Oxf Open Immunol. 2024; 5(1): iqae005. doi: 10.1093/oxfimm/iqae005. PMID: 39193474; PMCID: PMC11211616.
Cherie TJJ, Choong CSH, Abid MB, Weber MW, Yap ES, Seneviratne SL, et al. Immuno-Haematologic Aspects of Dengue Infection: Biologic Insights and Clinical Implications. Viruses. 2024;16(7):1090. doi: 10.3390/v16071090. PMID: 39066252; PMCID: PMC11281699.
Day ME, Puello YC, Mejía Sang ME, Diaz Brockmans EJ, Díaz Soto MF, Rivera Defilló SM, et al. Complete Blood Count Values Over Time in Young Children During the Dengue Virus Epidemic in the Dominican Republic From 2018 to 2020. Biomed Res Int. 2024; 2024:3716786. doi: 10.1155/2024/3716786. PMID: 39130533; PMCID: PMC11316910.
Zeb F, Haleem KS, Almuqbil M, Rashid M, Hussain W, Maqbool F, et al. Age, gender, and infectious status-wise assessments of hematological parameters among patients with dengue infection. Heliyon. 2024;10(13): e34053. doi: 10.1016/j.heliyon.2024.e34053. PMID: 39055808; PMCID: PMC11269918.
Halstead SB, Dans LF. Dengue infection and advances in dengue vaccines for children. Lancet Child Adolesc Health. 2019; 3(10):734-741. doi: 10.1016/S2352-4642(19)30205-6. PMID: 31378686.
Diep NT, Giang NT, Diu NTT, Nam NM, Khanh LV, Quang HV, et al. Complement receptor type 1 and 2 (CR1 and CR2) gene polymorphisms and plasma protein levels are associated with the Dengue disease severity. Sci Rep. 2023;13(1):17377. doi: 10.1038/s41598-023-44512-w. PMID: 37833411; PMCID: PMC10575961.
Kok BH, Lim HT, Lim CP, Lai NS, Leow CY, Leow CH. Dengue virus infection - a review of pathogenesis, vaccines, diagnosis and therapy. Virus Res. 2023; 324:199018. doi: 10.1016/j.virusres.2022.199018. PMID: 36493993.
Nacher M, Douine M, Gaillet M, Flamand C, Rousset D, Rousseau C, et al. Simultaneous dengue and COVID-19 epidemics: Difficult days ahead? PLoS Negl Trop Dis. 2020;14(8): e0008426. doi: 10.1371/journal.pntd.0008426. PMID: 32797035; PMCID: PMC7428060.
Stewart-Ibarra AM, Romero M, Hinds AQJ, Lowe R, Mahon R, Van Meerbeeck CJ, et al. Co-developing climate services for public health: Stakeholder needs and perceptions for the prevention and control of Aedes-transmitted diseases in the Caribbean. PLoS Negl Trop Dis. 2019;13(10): e0007772. doi: 10.1371/journal.pntd.0007772. PMID: 31658267; PMCID: PMC6837543.
Hasan MM, Hernández-Yépez PJ, de Los Angeles Rivera-Cabrera M, Sarkar A, Dos Santos Costa AC, Essar MY. Concurrent epidemics of dengue and COVID-19 in Peru: ¿Which way forward? Lancet Reg Health Am. 2022; 12:100277. doi: 10.1016/j.lana.2022.100277. PMID: 36776431; PMCID: PMC9903762.
Ministerio de Salud. República de El Salvador. Dirección de Epidemiología. Boletín Epidemiológico Semana 26 (del 26 de junio al 2 de julio 2022). Situación epidemiológica del Dengue. 2022. Disponible en: https://fi-admin.bvsalud.org/document/view/v954f#:~:text=A%20la%20SE04%20del%202023,con%20631%20casos%20en%202022.
Junior JBS, Massad E, Lobao-Neto A, Kastner R, Oliver L, Gallagher E. Epidemiology and costs of dengue in Brazil: a systematic literature review. Int J Infect Dis. 2022; 122:521-528. doi: 10.1016/j.ijid.2022.06.050. PMID: 35793756.
Márquez-Batista N, Plasencia-Lugo LI, Arias-Valdés Y. Protocolo de actuación para el correcto diagnóstico y tratamiento del dengue en Pediatría. Rev Ciencias Médicas. 2023; 27(3). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561-31942023000300011&lng=es.
Pantoja O, González D, Guzmán MG, Castro O, Martínez E. Descripción clínica de niños fallecidos por dengue hemorrágico durante la epidemia cubana de 1981. Rev cubana Pediatr. 2022; 94(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75312022000200008&lng=es.
Frasca F, Sorrentino L, Fracella M, D'Auria A, Coratti E, Maddaloni L, et al. An Update on the Entomology, Virology, Pathogenesis, and Epidemiology Status of West Nile and Dengue Viruses in Europe (2018-2023). Trop Med Infect Dis. 2024; 9(7):166. doi: 10.3390/tropicalmed9070166. PMID: 39058208; PMCID: PMC11281579.
Organización Panamericana de la Salud. Recomendaciones para la detección y el diagnóstico por laboratorio de infecciones por arbovirus en la Región de las Américas. Washington, D.C.; 2022. Disponible en: https://doi.org/10.37774/9789275325872.
Véliz-Castro TI, Contreras-Chirinos K, Duran-Mojica A, Chasillacta-Amores FB, Villamar-González FJ, Valero-Cedeño N. Complicaciones neurológicas asociadas a infección por virus dengue: una actualización. Dominio de las Ciencias. 2019; 5(1):774-791. Disponible en: https://dominiodelasciencias.com/ojs/index.php/es/article/view/1083
Seixas J, Giovanni Luz K, Pinto Junior V. Atualização Clínica sobre Diagnóstico, Tratamento e Prevenção da Dengue. Acta Med Port. 2024;37(2):126-135. Portuguese. doi: 10.20344/amp.20569. PMID: 38309298.
Chan C, Kwan Sze NS, Suzuki Y, Ohira T, Suzuki T, Begley TJ, et al. Dengue virus exploits the host tRNA epitranscriptome to promote viral replication. BioRxiv. 2023:2023.11.05.565734. doi: 10.1101/2023.11.05.565734. PMID: 37986976; PMCID: PMC10659268.
Sarker R, Roknuzzaman ASM, Haque MA, Islam MR, Kabir ER. Upsurge of dengue outbreaks in several WHO regions: Public awareness, vector control activities, and international collaborations are key to prevent spread. Health Sci Rep. 2024; 7(4): e2034. doi: 10.1002/hsr2.2034. PMID: 38655420; PMCID: PMC11035754.
Chen CH, Huang YC, Kuo KC, Li CC. Clinical features and dynamic ordinary laboratory tests differentiating dengue fever from other febrile illnesses in children. J Microbiol Immunol Infect. 2018;51(5):614-620. doi: 10.1016/j.jmii.2016.08.018. PMID: 28712817.
Narváez F, Montenegro C, Juárez JG, Zambrana JV, González K, Videa E, et al. Dengue severity by serotype and immune status in 19 years of pediatric clinical studies in Nicaragua. medRxiv. 2024: 2024.02.11.24302393. doi: 10.1101/2024.02.11.24302393. PMID: 38405964; PMCID: PMC10889012.
Vikhe VB, Khandol D, Faruqi AA, Reddy A. A study on the clinical profile of patients presenting with dengue fever and the precision prediction of dengue severity using platelet count at presentation. Cureus. 2024;16(6): e63255. doi: 10.7759/cureus.63255. PMID: 39070501; PMCID: PMC11281968.
Pan American Health Organization/World Health Organization. PAHO/WHO. Data—Dengue cases. 2022. Disponible en: https://www3. paho. org/data/index. php/en/mnu topics/indic adores dengue en/dengue nacional en/252 dengue pais ano en. html.
Pattnaik SS, Patil U, Aggarwal L, Patro S, Mishra P, Mohanty A. Exploring mean platelet volume and platelet count recovery in dengue patients: findings from an observational retrospective clinical study. Cureus. 2024; 16(7): e65553. doi: 10.7759/cureus.65553. PMID: 39192933; PMCID: PMC11347964.
Haro Sarango A, Chisag Pallmay E, Ruiz Sarzosa J, Caicedo Pozo J. Tipos y clasificación de las investigaciones. LATAM Revista Latinoamericana de Ciencias. 2024; 5(2): 956–966. https://doi.org/10.56712/latam.v5i2.1927
Fernández- Matías R. El Cálculo del Tamaño Muestral en Ciencias de la Salud: Recomendaciones y Guía Práctica. MOVE. 2023;5(1):481-503. Disponible en: https://publicaciones.lasallecampus.es/index.php/MOVE/article/view/915
Asamblea Nacional del Ecuador. Ley Orgánica de Protección de Datos Personales. 2021. Disponible en: https://www.telecomunicaciones.gob.ec/wp-content/uploads/2021/06/Ley-Organica-de-Datos-Personales.pdf
Asociación Médica Mundial. Declaración de Helsinki. Principios Éticos para las Investigaciones Médicas en seres humanos. 2020. Disponible en https://www.wma.net/es/policies-post/declaracion-de-helsinki-de-la-amm-principios-eticos-para-las-investigaciones-medicas-en-seres-humanos/
Ministerio de Salud Pública del Ecuador. Manual: Gestión interna de los residuos y desechos generados en los establecimientos de salud. Quito. 2019. Disponible en: https://aplicaciones.msp.gob.ec/salud/archivosdigitales/documentosDirecciones/dnn/archivos/AC00036-2019.pdf
Verma P, Baskey U, Choudhury KR, Dutta S, Bakshi S, Das R, et al. Changing pattern of circulating dengue serotypes in the endemic region: An alarming risk to the healthcare system during the pandemic. J Infect Public Health. 2023;16(12):2046-2057. doi: 10.1016/j.jiph.2023.10.014. PMID: 37944366.
Gurgel-Gonçalves R, Oliveira WK, Croda J. The greatest Dengue epidemic in Brazil: Surveillance, Prevention, and Control. Rev Soc Bras Med Trop. 2024; 57: e002032024. doi: 10.1590/0037-8682-0113-2024. PMID: 39319953; PMCID: PMC11415067.
Vogel MA, Silva GA, Otero-Rodríguez S, Deschutter EJ, Ramos Rincón JM. Seroprevalence of dengue IgG and associated risk factors in symptomatic and asymptomatic adults in Posadas (Misiones, Argentina), 2017-2019. J Infect Public Health. 2024;17(4):663-668. doi: 10.1016/j.jiph.2024.02.002. PMID: 38447322.
Lee SY, Shih HI, Lo WC, Lu TH, Chien YW. Discrepancies in dengue burden estimates: a comparative analysis of reported cases and global burden of disease study, 2010-2019. J Travel Med. 2024; 31(4): taae069. doi: 10.1093/jtm/taae069. PMID: 38696416; PMCID: PMC11149719.
Gohel VK, Gadhavi HM, Shingala HK, Jethva SD. A study on evaluation and correlation of serological methods and platelet count for diagnosis of dengue virus infection. J Vector Borne Dis. 2024. doi: 10.4103/JVBD.JVBD_45_23. PMID: 39113381.
Sarkar S, Ghosh A, Nag S, Das S, Sarkar D. An Observational Study to Find the Association of Viral Load, NS1 Antigen, IgG Antibody, and other laboratory parameters with the outcome of dengue patients in Eastern India. Cureus. 2024;16(6): e63516. doi: 10.7759/cureus.63516. PMID: 39081415; PMCID: PMC11288338.
Vikhe VB, Khandol D, Faruqi AA, Reddy A. A Study on the clinical profile of patients presenting with dengue fever and the precision prediction of dengue severity using platelet count at presentation. Cureus. 2024;16(6): e63255. doi: 10.7759/cureus.63255. PMID: 39070501; PMCID: PMC11281968.
Khan KA, Qureshi SU. Role of granulocyte colony stimulating factor (G-CSF) in dengue patients with severe thrombocytopenia. J Pak Med Assoc. 2024;74(2):272-276. doi: 10.47391/JPMA.8474. PMID: 38419225.
Asha J, Baiju NM, Innah SJ, Rafi A, John BM. Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center. Asian J Transfus Sci. 2023;17(1):21-27. doi: 10.4103/ajts.AJTS_24_20. PMID: 37188027; PMCID: PMC10180782.
Fiora MB, Gonzalvez ML, Aguirre JP, Bacigalupo A, Garnero A, Rosa AM, et al. Observational study of clinical, epidemiological, and laboratory characteristics of pediatric patients with dengue in the city of Córdoba. Arch Argent Pediatr. 2024;122(1): e202202972. doi: 10.5546/aap.2022-02972.eng. PMID: 37639337.
John KJ, Gunasekaran K, Prasad JD, Mathew D, Das S, Sultan N, et al. Predictors of major bleeding and mortality in dengue infection: A retrospective observational study in a tertiary care centre in South India. Interdiscip Perspect Infect Dis. 2019; 2019:4823791. doi: 10.1155/2019/4823791. PMID: 31565054; PMCID: PMC6746148.
Phung NTN, Tran MN, Tran TT, Vo DM. Clinical picture and risk factors for severity of SARS-CoV-2 and dengue coinfection in children: Experience From a tertiary hospital in Vietnam. Cureus. 2024; 16(8): e66535. doi: 10.7759/cureus.66535. PMID: 39246953; PMCID: PMC11381082.
Singh A, Abhinay A, Prasad R, Mishra OP. Clinical, biochemical and outcome profile of dengue fever in hospitalised children in Eastern Uttar Pradesh, India. Sudan J Paediatr. 2023;23(2):171-176. doi: 10.24911/SJP.106-1608787494. PMID: 38380401; PMCID: PMC10876267.
Márquez S, Lee G, Gutiérrez B, Bennett S, Coloma J, Eisenberg JNS, et al. Phylogenetic Analysis of Transmission Dynamics of Dengue in Large and Small Population Centers, Northern Ecuador. Emerg Infect Dis. 2023; 29(5):888-897. doi: 10.3201/eid2905.221226. PMID: 37080979; PMCID: PMC10124659.
DOI: https://doi.org/10.23857/pc.v10i5.9465
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