Colangiocarcinoma extrahepático avanzado: análisis de un caso clínico y revisión de la literatura
Resumen
El colangiocarcinoma extrahepático es una neoplasia maligna poco frecuente con un pronóstico reservado debido a su diagnóstico tardío. Se presenta el caso de un paciente masculino de 67 años con antecedentes de hipertensión y diabetes mellitus, que acude con dolor en hipocondrio derecho, náuseas y vómitos biliosos. A través de estudios de laboratorio e imagenológicos, se confirmó el diagnóstico de colangiocarcinoma extrahepático avanzado. Se discuten los hallazgos clínicos, diagnósticos diferenciales, opciones terapéuticas y pronóstico de la enfermedad con base en la literatura reciente.
Palabras clave
Referencias
Qurashi M, Vithayathil M, Khan SA. Epidemiology of Cholangiocarcinoma. European Journal of Surgical Oncology : The Journal of the European Society of
Surgical Oncology and the British Association of Surgical Oncology. 2023;:107064. doi:10.1016/j.ejso.2023.107064.
Krenzien F, Nevermann N, Krombholz A, et al. Treatment of Intrahepatic Cholangiocarcinoma-a Multidisciplinary Approach. Cancers. 2022;14(2):362. doi:10.3390/cancers14020362.
Khan SA, Tavolari S, Brandi G. Cholangiocarcinoma: Epidemiology and Risk Factors. Liver International : Official Journal of the International Association for the Study of the Liver. 2019;39 Suppl 1:19-31. doi:10.1111/liv.14095.
Labib PL, Goodchild G, Pereira SP. Molecular Pathogenesis of Cholangiocarcinoma. BMC Cancer. 2019;19(1):185. doi:10.1186/s12885-019-5391-0.
5. Clements O, Eliahoo J, Kim JU, Taylor-Robinson SD, Khan SA. Risk Factors for Intrahepatic and Extrahepatic Cholangiocarcinoma: A Systematic Review and Meta- Analysis. Journal of Hepatology. 2020;72(1):95-103. doi:10.1016/j.jhep.2019.09.007.
Merters J, Lamarca A. Integrating Cytotoxic, Targeted and Immune Therapies for Cholangiocarcinoma. Journal of Hepatology. 2023;78(3):652-657. doi:10.1016/j.jhep.2022.11.005.
Khosla D, Misra S, Chu PL, et al. Cholangiocarcinoma: Recent Advances in Molecular Pathobiology and Therapeutic Approaches. Cancers. 2024;16(4):801. doi:10.3390/cancers16040801.
Ilyas SI, Affo S, Goyal L, et al. Cholangiocarcinoma - Novel Biological Insights and Therapeutic Strategies. Nature Reviews. Clinical Oncology. 2023;20(7):470-486. doi:10.1038/s41571-023-00770-1.
Uson Junior PLS, Borad MJ. Precision Approaches for Cholangiocarcinoma: Progress in Clinical Trials and Beyond. Expert Opinion on Investigational Drugs. 2022;31(1):125-131. doi:10.1080/13543784.2022.2017882.
Vignone A, Biancaniello F, Casadio M, et al. Emerging Therapies for Advanced Cholangiocarcinoma: An Updated Literature Review. Journal of Clinical Medicine. 2021;10(21):4901. doi:10.3390/jcm10214901.
Kankeu Fonkoua LA, Serrano Uson Junior PL, Mody K, et al. Novel and Emerging Targets for Cholangiocarcinoma Progression: Therapeutic Implications. Expert
Opinion on Therapeutic Targets. 2022;26(1):79-92. doi:10.1080/14728222.2022.2029412.
Wang J, Liu S, Cao Y, Chen Y. Overcoming Treatment Resistance in Cholangiocarcinoma: Current Strategies, Challenges, and Prospects. Frontiers in Cell and Developmental Biology. 2024;12:1408852. doi:10.3389/fcell.2024.1408852.
Putatunda V, Jusakul A, Roberts L, Wang XW. Genetic, Epigenetic, and Microenvironmental Drivers of Cholangiocarcinoma. The American Journal of Pathology. 2024;:S0002-9440(24)00406-1. doi:10.1016/j.ajpath.2024.10.013.
Maemura K, Natsugoe S, Takao S. Molecular Mechanism of Cholangiocarcinoma Carcinogenesis. Journal of Hepato-Biliary-Pancreatic Sciences. 2014;21(10):754-60. doi:10.1002/jhbp.126.
Buckholz AP, Brown RS. Cholangiocarcinoma: Diagnosis and Management. Clinics in Liver Disease. 2020;24(3):421-436. doi:10.1016/j.cld.2020.04.005.
Forner A, Vidili G, Rengo M, et al. Clinical Presentation, Diagnosis and Staging of Cholangiocarcinoma. Liver International : Official Journal of the International Association for the Study of the Liver. 2019;39 Suppl 1:98-107. doi:10.1111/liv.14086.
Bowlus CL, Lim JK, Lindor KD. AGA Clinical Practice Update on Surveillance for Hepatobiliary Cancers in Patients With Primary Sclerosing Cholangitis: Expert Review. Clinical Gastroenterology and Hepatology : The Official Clinical Practice Journal of the American Gastroenterological Association. 2019;17(12):2416-2422. doi:10.1016/j.cgh.2019.07.011.
Cao J, Srinivas-Rao S, Mroueh N, et al. Cholangiocarcinoma Imaging: From Diagnosis to Response Assessment. Abdominal Radiology (New York). 2024;49(5):1699-1715. doi:10.1007/s00261-024-04267-y.
Elmunzer BJ, Maranki JL, Gómez V, et al. ACG Clinical Guideline: Diagnosis and Management of Biliary Strictures. The American Journal of Gastroenterology. 2023;118(3):405-426. doi:10.14309/ajg.0000000000002190.
Lamarca A, Santos-Laso A, Utpatel K, et al. Liver Metastases of Intrahepatic Cholangiocarcinoma: Implications for an Updated Staging System. Hepatology (Baltimore, Md.). 2021;73(6):2311-2325. doi:10.1002/hep.31598.
Turner KM, Delman AM, Kharofa J, et al. A National Assessment of T2 Staging for Intrahepatic Cholangiocarcinoma and the Poor Prognosis Associated With Multifocality. Annals of Surgical Oncology. 2022;29(8):5094-5102. doi:10.1245/s10434-022-11762-3.
DOI: https://doi.org/10.23857/pc.v10i2.9017
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