Nowadays, speaking English is not an advantage, but a basic skill that people must develop in their training, which will allow them to be competitive in the global labor market. The objective was to identify the relationship of brain gymnastics with the meaningful learning of 2nd year English students of the Middle Level, course A, of the Dr. Alfredo Pérez Guerrero Educational Unit, Guano canton, Chimborazo province, during the school year September 2023 - June 2024 ”. The research methodology applied in this study was a "mixed" approach and the design of this research was of a "quasi-experimental" type. Likewise, the scope of the research was descriptive. Thus, "field and documentary research" supported this study and the method to analyze generalities was "deductive - inductive". In addition, the "sample" of the present study corresponds to the "population" of 25 students of the Experimental Group. Therefore, a questionnaire with 4 items on language skills was applied to collect information in the pretest and posttest. Thus, the information was collected in a database and analyzed using descriptive and inferential statistics where the paired samples parametric T test was applied to verify the hypothesis using Jamovi software. The results were illustrated in graphs with mathematical values, so the results showed that with 24 degrees of freedom and with a significance level (α) of 0.05, the p value = 0.001 is less than α = 0.05. Similarly, the calculated Student T is 18, which is higher than 1.711 from the Student T test distribution table. In summary, Ho is rejected and H1 is accepted. It means that if a brain gym program is applied, significant English language learning will be achieved by students.