The research aimed the relationship between work motivation and work performance in a specific public university. So, what is the relationship between work motivation and work performance in administrative collaborators at the National University of Moquegua Campus, 2017? A non-experimental, transversal and correlational design study was carried out. Survey was used as a technique and two questionnaires were applied to a stratified random sample of 76 administrative collaborators at National University of Moquegua. Based on the research conclusions, this paper indicates there is a highly significant relationship between work motivation and work performance, with a bilateral asymptotic significance level of p = 0.003 < 0.01; when the administrative staff at National University of Moquegua is better motivated, then there will be a better performance in their tasks. Internal Motivation, is the dimension which has a greater influence in work performance.